AustralieFrV1, Main, Exploration, bibRecord, 003279

ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection

Identifieur interne : 003279 ( Main/Exploration ); précédent : 003278; suivant : 003280

ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection

Auteurs : Tarik Asselah [France] ; Stefan Zeuzem [Allemagne] ; Vicente Soriano [Espagne] ; Jean-Pierre Bronowicki [France] ; Ansgar W. Lohse [Allemagne] ; Beat Müllhaupt [Suisse] ; Marcus Schuchmann [Allemagne] ; Marc Bourlière [France] ; Maria Buti [Espagne] ; Stuart K. Roberts [Australie] ; Edward J. Gane [Nouvelle-Zélande] ; Jerry O. Stern [États-Unis] ; Florian Voss [Allemagne] ; Patrick Baum [Allemagne] ; John-Paul Gallivan [Allemagne] ; Wulf O. Böcher [Allemagne] ; Federico J. Mensa [États-Unis]

Source :

PLoS ONE [ 1932-6203 ] ; 2015.

RBID : PMC:4674133

Descripteurs français

KwdFr :
- Acrylates (pharmacologie), Adulte d'âge moyen, Antiviraux (pharmacologie), Anémie (diagnostic), Anémie (étiologie), Benzimidazoles (pharmacologie), Femelle, Génotype, Hepacivirus (), Humains, Hépatite C (), Hépatite C (traitement médicamenteux), Hépatite C (virologie), Interférons (métabolisme), Mâle, Oligopeptides (pharmacologie), Polymorphisme de nucléotide simple (génétique), Pyrophosphatases (génétique), Ribavirine (pharmacologie), Réaction de polymérisation en chaine en temps réel, Thiazoles (pharmacologie).
MESH :
- diagnostic : Anémie.
- génétique : Polymorphisme de nucléotide simple, Pyrophosphatases.
- métabolisme : Interférons.
- pharmacologie : Acrylates, Antiviraux, Benzimidazoles, Oligopeptides, Ribavirine, Thiazoles.
- traitement médicamenteux : Hépatite C.
- virologie : Hépatite C.
- étiologie : Anémie.
- Adulte d'âge moyen, Femelle, Génotype, Hepacivirus, Humains, Hépatite C, Mâle, Réaction de polymérisation en chaine en temps réel.

English descriptors

KwdEn :
- Acrylates (pharmacology), Anemia (diagnosis), Anemia (etiology), Antiviral Agents (pharmacology), Benzimidazoles (pharmacology), Female, Genotype, Hepacivirus (drug effects), Hepatitis C (complications), Hepatitis C (drug therapy), Hepatitis C (virology), Humans, Interferons (metabolism), Male, Middle Aged, Oligopeptides (pharmacology), Polymorphism, Single Nucleotide (genetics), Pyrophosphatases (genetics), Real-Time Polymerase Chain Reaction, Ribavirin (pharmacology), Thiazoles (pharmacology).
MESH :
- chemical , genetics : Pyrophosphatases.
- chemical , metabolism : Interferons.
- chemical , pharmacology : Acrylates, Antiviral Agents, Benzimidazoles, Oligopeptides, Ribavirin, Thiazoles.
- complications : Hepatitis C.
- diagnosis : Anemia.
- drug effects : Hepacivirus.
- drug therapy : Hepatitis C.
- etiology : Anemia.
- genetics : Polymorphism, Single Nucleotide.
- virology : Hepatitis C.
- Female, Genotype, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction.

Abstract

Background & Aim

Whether inosine triphosphatase (ITPA) gene polymorphisms predict anemia during interferon-free therapy in chronic hepatitis C virus (HCV)-infected patients is unknown. We examined the relationship between two ITPA polymorphisms, anemia, and sustained virological response 12 weeks post-treatment (SVR12) in patients receiving the NS3/4A protease inhibitor faldaprevir, the non-nucleoside polymerase inhibitor deleobuvir, and ribavirin.

Methods

HCV genotype 1-infected, treatment-naïve patients (N = 362) were randomized and treated in one of five treatment arms with faldaprevir and deleobuvir with or without ribavirin. Two ITPA polymorphisms (rs1127354 and rs6051702) were genotyped and defined as ITPA-deficient (rs1127354 AA or AC; rs6051702 CC or CA) or ITPA-non-deficient (rs1127354 CC; rs6051702 AA) according to their association with ITPA deficiency. Baseline and on-treatment variables associated with anemia and SVR12 were identified using logistic regression.

Results

In the pooled ribavirin-containing arms, 10.1% (32/316) of patients experienced on-treatment hemoglobin <10 g/dL, and 32.6% (103/316) experienced on-treatment hemoglobin <10 g/dL or a change from baseline ≥3.5 g/dL. Of the latter group, 99% (102/103) had the ITPA-non-deficient rs1127354 genotype. Other variables associated with on-treatment hemoglobin <10 g/dL or a decrease ≥3.5 g/dL were age, baseline hemoglobin, rs6051702 genotype, and plasma ribavirin concentration. In a multivariate analysis, high plasma ribavirin concentration, low baseline hemoglobin, HCV genotype 1b, and IL28B genotype CC were associated with higher SVR12.

Conclusions

The ITPA rs1127354 CC and rs6051702 AA genotypes may predict ribavirin-induced anemia during treatment with interferon-free, ribavirin-containing regimens. With this interferon-free regimen, SVR was associated with ribavirin levels, but not with anemia or ITPA genotypes.

Trial Registration

ClinicalTrials.gov: NCT01132313

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674133

DOI: 10.1371/journal.pone.0144004
PubMed: 26650626
PubMed Central: 4674133

Affiliations:

Le document en format XML

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 Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>ITPA</italic>
 Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection</title>
<author><name sortKey="Asselah, Tarik" sort="Asselah, Tarik" uniqKey="Asselah T" first="Tarik" last="Asselah">Tarik Asselah</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Lohse, Ansgar W" sort="Lohse, Ansgar W" uniqKey="Lohse A" first="Ansgar W." last="Lohse">Ansgar W. Lohse</name>
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<author><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name>
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</nlm:aff>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d’hépato-gastro-entérologie, Hôpital Saint Joseph, Marseille</wicri:regionArea>
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</author>
<author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name>
<affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Liver Unit, Hospital Universitario Valle de Hebron and CIBERehd del Instituto Carlos III, Barcelona, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Liver Unit, Hospital Universitario Valle de Hebron and CIBERehd del Instituto Carlos III, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K." last="Roberts">Stuart K. Roberts</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Gastroenterology, Alfred Hospital, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Gastroenterology, Alfred Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gane, Edward J" sort="Gane, Edward J" uniqKey="Gane E" first="Edward J." last="Gane">Edward J. Gane</name>
<affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Auckland Clinical Studies, Auckland, New Zealand</addr-line>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Auckland Clinical Studies, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stern, Jerry O" sort="Stern, Jerry O" uniqKey="Stern J" first="Jerry O." last="Stern">Jerry O. Stern</name>
<affiliation wicri:level="2"><nlm:aff id="aff012"><addr-line>Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Voss, Florian" sort="Voss, Florian" uniqKey="Voss F" first="Florian" last="Voss">Florian Voss</name>
<affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim</wicri:regionArea>
<wicri:noRegion>Ingelheim</wicri:noRegion>
<wicri:noRegion>Ingelheim</wicri:noRegion>
<wicri:noRegion>Ingelheim</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baum, Patrick" sort="Baum, Patrick" uniqKey="Baum P" first="Patrick" last="Baum">Patrick Baum</name>
<affiliation wicri:level="1"><nlm:aff id="aff014"><addr-line>Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach</wicri:regionArea>
<wicri:noRegion>Biberach</wicri:noRegion>
<wicri:noRegion>Biberach</wicri:noRegion>
<wicri:noRegion>Biberach</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gallivan, John Paul" sort="Gallivan, John Paul" uniqKey="Gallivan J" first="John-Paul" last="Gallivan">John-Paul Gallivan</name>
<affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim</wicri:regionArea>
<wicri:noRegion>Ingelheim</wicri:noRegion>
<wicri:noRegion>Ingelheim</wicri:noRegion>
<wicri:noRegion>Ingelheim</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bocher, Wulf O" sort="Bocher, Wulf O" uniqKey="Bocher W" first="Wulf O." last="Böcher">Wulf O. Böcher</name>
<affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim</wicri:regionArea>
<wicri:noRegion>Ingelheim</wicri:noRegion>
<wicri:noRegion>Ingelheim</wicri:noRegion>
<wicri:noRegion>Ingelheim</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mensa, Federico J" sort="Mensa, Federico J" uniqKey="Mensa F" first="Federico J." last="Mensa">Federico J. Mensa</name>
<affiliation wicri:level="2"><nlm:aff id="aff012"><addr-line>Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrylates (pharmacology)</term>
<term>Anemia (diagnosis)</term>
<term>Anemia (etiology)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Benzimidazoles (pharmacology)</term>
<term>Female</term>
<term>Genotype</term>
<term>Hepacivirus (drug effects)</term>
<term>Hepatitis C (complications)</term>
<term>Hepatitis C (drug therapy)</term>
<term>Hepatitis C (virology)</term>
<term>Humans</term>
<term>Interferons (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Oligopeptides (pharmacology)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Pyrophosphatases (genetics)</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Ribavirin (pharmacology)</term>
<term>Thiazoles (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acrylates (pharmacologie)</term>
<term>Adulte d'âge moyen</term>
<term>Antiviraux (pharmacologie)</term>
<term>Anémie (diagnostic)</term>
<term>Anémie (étiologie)</term>
<term>Benzimidazoles (pharmacologie)</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Hepacivirus ()</term>
<term>Humains</term>
<term>Hépatite C ()</term>
<term>Hépatite C (traitement médicamenteux)</term>
<term>Hépatite C (virologie)</term>
<term>Interférons (métabolisme)</term>
<term>Mâle</term>
<term>Oligopeptides (pharmacologie)</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Pyrophosphatases (génétique)</term>
<term>Ribavirine (pharmacologie)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Thiazoles (pharmacologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Pyrophosphatases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferons</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acrylates</term>
<term>Antiviral Agents</term>
<term>Benzimidazoles</term>
<term>Oligopeptides</term>
<term>Ribavirin</term>
<term>Thiazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatitis C</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Anemia</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Anémie</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hepacivirus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anemia</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Polymorphisme de nucléotide simple</term>
<term>Pyrophosphatases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Interférons</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acrylates</term>
<term>Antiviraux</term>
<term>Benzimidazoles</term>
<term>Oligopeptides</term>
<term>Ribavirine</term>
<term>Thiazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite C</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Anémie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Hepacivirus</term>
<term>Humains</term>
<term>Hépatite C</term>
<term>Mâle</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background & Aim</title>
<p>Whether inosine triphosphatase (<italic>ITPA</italic>
) gene polymorphisms predict anemia during interferon-free therapy in chronic hepatitis C virus (HCV)-infected patients is unknown. We examined the relationship between two <italic>ITPA</italic>
 polymorphisms, anemia, and sustained virological response 12 weeks post-treatment (SVR12) in patients receiving the NS3/4A protease inhibitor faldaprevir, the non-nucleoside polymerase inhibitor deleobuvir, and ribavirin.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>HCV genotype 1-infected, treatment-naïve patients (N = 362) were randomized and treated in one of five treatment arms with faldaprevir and deleobuvir with or without ribavirin. Two <italic>ITPA</italic>
 polymorphisms (rs1127354 and rs6051702) were genotyped and defined as ITPA-deficient (rs1127354 AA or AC; rs6051702 CC or CA) or ITPA-non-deficient (rs1127354 CC; rs6051702 AA) according to their association with ITPA deficiency. Baseline and on-treatment variables associated with anemia and SVR12 were identified using logistic regression.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>In the pooled ribavirin-containing arms, 10.1% (32/316) of patients experienced on-treatment hemoglobin <10 g/dL, and 32.6% (103/316) experienced on-treatment hemoglobin <10 g/dL or a change from baseline ≥3.5 g/dL. Of the latter group, 99% (102/103) had the ITPA-non-deficient rs1127354 genotype. Other variables associated with on-treatment hemoglobin <10 g/dL or a decrease ≥3.5 g/dL were age, baseline hemoglobin, rs6051702 genotype, and plasma ribavirin concentration. In a multivariate analysis, high plasma ribavirin concentration, low baseline hemoglobin, HCV genotype 1b, and <italic>IL28B</italic>
 genotype CC were associated with higher SVR12.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p>The <italic>ITPA</italic>
 rs1127354 CC and rs6051702 AA genotypes may predict ribavirin-induced anemia during treatment with interferon-free, ribavirin-containing regimens. With this interferon-free regimen, SVR was associated with ribavirin levels, but not with anemia or <italic>ITPA</italic>
 genotypes.</p>
</sec>
<sec id="sec005"><title>Trial Registration</title>
<p>ClinicalTrials.gov: <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT01132313">NCT01132313</ext-link>
</p>
</sec>
</div>
</front>
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<author><name sortKey="Reddy, Kr" uniqKey="Reddy K">KR Reddy</name>
</author>
<author><name sortKey="Hassanein, T" uniqKey="Hassanein T">T Hassanein</name>
</author>
<author><name sortKey="Berenguer, M" uniqKey="Berenguer M">M Berenguer</name>
</author>
<author><name sortKey="Fleischer Stepniewska, K" uniqKey="Fleischer Stepniewska K">K Fleischer-Stepniewska</name>
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<author><name sortKey="Poordad, F" uniqKey="Poordad F">F Poordad</name>
</author>
<author><name sortKey="Manns, Mp" uniqKey="Manns M">MP Manns</name>
</author>
<author><name sortKey="Bronowicki, Jp" uniqKey="Bronowicki J">JP Bronowicki</name>
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<author><name sortKey="Rajender Reddy, K" uniqKey="Rajender Reddy K">K Rajender Reddy</name>
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<author><name sortKey="Harrison, Sa" uniqKey="Harrison S">SA Harrison</name>
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<author><name sortKey="Asselah, T" uniqKey="Asselah T">T Asselah</name>
</author>
<author><name sortKey="Foster, Gr" uniqKey="Foster G">GR Foster</name>
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<author><name sortKey="Zeuzem, S" uniqKey="Zeuzem S">S Zeuzem</name>
</author>
<author><name sortKey="Sarrazin, C" uniqKey="Sarrazin C">C Sarrazin</name>
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<author><name sortKey="Moreno, C" uniqKey="Moreno C">C Moreno</name>
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<author><name sortKey="Ali, Rj" uniqKey="Ali R">RJ Ali</name>
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<author><name sortKey="Dore, Gj" uniqKey="Dore G">GJ Dore</name>
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<author><name sortKey="Sievert, W" uniqKey="Sievert W">W Sievert</name>
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<author><name sortKey="Mccaughan, Gw" uniqKey="Mccaughan G">GW McCaughan</name>
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<author><name sortKey="Abe, H" uniqKey="Abe H">H Abe</name>
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<author><name sortKey="Miki, D" uniqKey="Miki D">D Miki</name>
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<author><name sortKey="Ochi, H" uniqKey="Ochi H">H Ochi</name>
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<author><name sortKey="Furusyo, N" uniqKey="Furusyo N">N Furusyo</name>
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<author><name sortKey="Nakamuta, M" uniqKey="Nakamuta M">M Nakamuta</name>
</author>
<author><name sortKey="Kajiwara, E" uniqKey="Kajiwara E">E Kajiwara</name>
</author>
<author><name sortKey="Nomura, H" uniqKey="Nomura H">H Nomura</name>
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<author><name sortKey="Dohmen, K" uniqKey="Dohmen K">K Dohmen</name>
</author>
</analytic>
</biblStruct>
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<author><name sortKey="Muir, Aj" uniqKey="Muir A">AJ Muir</name>
</author>
<author><name sortKey="Sulkowski, Ms" uniqKey="Sulkowski M">MS Sulkowski</name>
</author>
<author><name sortKey="Ge, D" uniqKey="Ge D">D Ge</name>
</author>
<author><name sortKey="Fellay, J" uniqKey="Fellay J">J Fellay</name>
</author>
<author><name sortKey="Shianna, Kv" uniqKey="Shianna K">KV Shianna</name>
</author>
</analytic>
</biblStruct>
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<author><name sortKey="Vidaud, M" uniqKey="Vidaud M">M Vidaud</name>
</author>
<author><name sortKey="Marcellin, P" uniqKey="Marcellin P">P Marcellin</name>
</author>
<author><name sortKey="Asselah, T" uniqKey="Asselah T">T Asselah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Afdhal, N" uniqKey="Afdhal N">N Afdhal</name>
</author>
<author><name sortKey="Zeuzem, S" uniqKey="Zeuzem S">S Zeuzem</name>
</author>
<author><name sortKey="Kwo, P" uniqKey="Kwo P">P Kwo</name>
</author>
<author><name sortKey="Chojkier, M" uniqKey="Chojkier M">M Chojkier</name>
</author>
<author><name sortKey="Gitlin, N" uniqKey="Gitlin N">N Gitlin</name>
</author>
<author><name sortKey="Puoti, M" uniqKey="Puoti M">M Puoti</name>
</author>
</analytic>
</biblStruct>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Nouvelle-Zélande</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Catalogne</li>
<li>Communauté de Madrid</li>
<li>Connecticut</li>
<li>District de Darmstadt</li>
<li>Grand Est</li>
<li>Hambourg</li>
<li>Hesse (Land)</li>
<li>Lorraine (région)</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhénanie-Palatinat</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Barcelone</li>
<li>Francfort-sur-le-Main</li>
<li>Hambourg</li>
<li>Madrid</li>
<li>Marseille</li>
<li>Mayence</li>
<li>Melbourne</li>
<li>Nancy</li>
<li>Vandœuvre-lès-Nancy</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Asselah, Tarik" sort="Asselah, Tarik" uniqKey="Asselah T" first="Tarik" last="Asselah">Tarik Asselah</name>
</noRegion>
<name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name>
<name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name>
</country>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name>
</region>
<name sortKey="Baum, Patrick" sort="Baum, Patrick" uniqKey="Baum P" first="Patrick" last="Baum">Patrick Baum</name>
<name sortKey="Bocher, Wulf O" sort="Bocher, Wulf O" uniqKey="Bocher W" first="Wulf O." last="Böcher">Wulf O. Böcher</name>
<name sortKey="Gallivan, John Paul" sort="Gallivan, John Paul" uniqKey="Gallivan J" first="John-Paul" last="Gallivan">John-Paul Gallivan</name>
<name sortKey="Lohse, Ansgar W" sort="Lohse, Ansgar W" uniqKey="Lohse A" first="Ansgar W." last="Lohse">Ansgar W. Lohse</name>
<name sortKey="Schuchmann, Marcus" sort="Schuchmann, Marcus" uniqKey="Schuchmann M" first="Marcus" last="Schuchmann">Marcus Schuchmann</name>
<name sortKey="Voss, Florian" sort="Voss, Florian" uniqKey="Voss F" first="Florian" last="Voss">Florian Voss</name>
</country>
<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Soriano, Vicente" sort="Soriano, Vicente" uniqKey="Soriano V" first="Vicente" last="Soriano">Vicente Soriano</name>
</region>
<name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Roberts, Stuart K" sort="Roberts, Stuart K" uniqKey="Roberts S" first="Stuart K." last="Roberts">Stuart K. Roberts</name>
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</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Gane, Edward J" sort="Gane, Edward J" uniqKey="Gane E" first="Edward J." last="Gane">Edward J. Gane</name>
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</country>
<country name="États-Unis"><region name="Connecticut"><name sortKey="Stern, Jerry O" sort="Stern, Jerry O" uniqKey="Stern J" first="Jerry O." last="Stern">Jerry O. Stern</name>
</region>
<name sortKey="Mensa, Federico J" sort="Mensa, Federico J" uniqKey="Mensa F" first="Federico J." last="Mensa">Federico J. Mensa</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection

ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection

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	Serveur d'exploration sur les relations entre la France et l'Australie
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